GcMAF is a natural immunotherapy product that cures Cancer

GcMAF Will help Your Immune system  

and Bad law kills,everyday

and Britain has the worst medical laws in Europe. The 1939 Cancer Act makes it illegal to discuss the possibility cancer can be cured, which is partly why 160,000 people die unnecessarily of cancer in Britain every year. ………………………….

“NAGA”lase a protein vaccination blocks the gcmaf and there may be a connection to the surpents that were called “NAGA” just thinking because its called “NAGA”lase https://www.youtube.com/watch?v=cALgIHETMDU

GcMAF and the life and death of an autism quack


[Editor’s note: This is an extra bonus post that has appeared elsewhere. This week’s post will appear in several hours.]

A mysterious apparent suicide and conspiracy theories

Three weeks ago, those of us who combat the antivaccine movement noted the then-very recent death of an autism quack and antivaccinationist (but I repeat myself) who’s been big in the “autism biomed” movement for a long time and was a regular fixture at autism quackfests like Autism ONE for many years. I’m referring, of course, to Jeff Bradstreet, whose body was found in a river on June 19, dead from a gunshot wound to the chest that appeared to have been self-inflicted. It didn’t take long (less than a week) for the antivaccine movement to start speculating about conspiracies in which Bradstreet had been “bumped off” by big pharma, as represented by comments like these:

  • “It’s obvious that he was deliberately killed off because he spoke out against federal deceit, CDC, etc and was a life-saver for many like myself.”
  • “He did NOT kill himself! He was murdered for who he was speaking against, what he knew, and what he was doing about it. He was brilliant kind compassionate doctor with amazing abilities to heal. He was taken. Stopped. Silenced.”
  • “If this does not stink to high heaven I don’t know what does. A fisherman finds his body with a gunshot wound that appears to be a self inflicted. Just how the hell would they know that. Amazingly they happen to find the gun in the river. Wow that is some amazing detective work.”
  • “What a tragic loss of a beloved doctor. I pray the authorities get to the bottom of this story…it seems highly unlikely that a Christian man would shoot himself in thy chest and conveniently fall into a river.”

You get the idea. Meanwhile, others insinuated the existence of, basically, pharma hit squads. Not long afterward, Bradstreet’s family started a GoFundMe page to “find the truth.”

Let me just say one thing. I understand, to some extent, what the Bradstreet family is going through. My family has not escaped without having had one of its members commit suicide. Although it was someone I wasn’t particularly close to, he was very close to family members I am close to. So I understand better than most the pain they are going through. They do have my sympathy. I’ve been there.

That being said, it appears that more information is coming out about what happened in the days leading to Bradstreet’s death. It’s even started to filter out to major media outlets, as in this story published yesterday in the Washington Post, “The mysterious death of a doctor who peddled autism ‘cures’ to thousands“:

James Jeffrey Bradstreet was one of the world’s most famous — or infamous — physicians. He believed vaccines caused autism. He even testified so before Congress. Twice.

But he didn’t just rail against Big Pharma. He also tried to beat it.

Bradstreet offered thousands of autism patients around the globe controversial treatments. He claimed he could effectively cure kids of their autism, cancer and other maladies simply by injecting them with protein shots.

When Bradstreet’s body was found last month in the Rocky Broad River in mountainous North Carolina with a bullet wound to the chest, therefore, friends, family members and patients pointed fingers at drug corporations. The FDA. Anyone but Bradstreet.

“He did not kill himself!” one patient’s parent wrote online.

“May God have vengeance quickly on the evil doers who murdered him!” wrote another.

From this story, we also learn that Bradstreet’s family had quickly raised $33,000 to investigate his death and had used the money to hire private investigators. I rather suspect that, like John F. Kennedy, the assassination conspiracy theories surrounding his death will never die, although they will only be known to the dark underbelly of the antivaccine movement and autism quackery.

What really happened? The FDA was closing in.

Conspiracy theories aside, we’re finally learning what appears to be the event that might have pushed Bradstreet to kill himself. It turns out that the day before he apparently killed himself, his office was the target of a federal search warrant in relation to his use of an unapproved drug to treat autism, GcMAF. Readers were kind enough to supply me with acopy of the search warrant. Basically, the warrant gave permission to search the Bradstreet Wellness Center in Buford, GA for “records, documents and items” related to:

  • All Globulin component Macrophage Activating Factor (GCMAF), GC-Globulin, and/or any other products or component substances thereof that constitute misbranded drugs under the Federal Food, Drug, and Cosmetic Act.
  • All records, in whatever form, associated with or pertaining to the acquisition, possession, distribution of unapproved drugs, prescriptions, and/or health care products. The records to be seized include those related to the brokering, ordering, purchasing, shipping, sale, and distribution of any drugs, including business journals and ledgers; tax records, and related work papers; purchase and sales records; communications; bank and financial records; shipment/transport records; supplier and customer records; regulatory compliance records and communications with federal, state, and local authorities; and any unopened mail addressed to or from the companies mentioned therein.

The warrant also authorized authorities to search for “all books, records, and documents” identifying current and former employees, any and all electronic, digital, and paper records relating to GcMAF, computers and peripherals, financial records, and more. You get the idea. As the news story I referenced above put it, whether or not any doubt remains over whether Bradstreet did indeed commit suicide, it’s clear that his use of dubious autism treatments had finally caught up with him after all these years. He was definitely in the FDA’s sights for his autism quackery. Strangely enough (to me) and frustratingly, it was not all his previous quackery that finally led to what one could only have hoped, had Bradstreet not killed himself, the beginning of the end of his empire of quackery and his taking up residence in a federal penitentiary. Remember, this is a guy who peddled hyperbaric oxygen chambers, chelation therapy, bogus stem cell treatments, hormone injections, secretin, and just about every sort of “autism biomed” quackery you can imagine, and then some. Let’s just put it this way. Bradstreet has in the past advocated exorcism to treat autism, although in the Autism Omnibus hearing, where he appeared as an expert witness for the complainants, he denied ever having performed exorcismsfor autism. Yet it was GcMAF that finally led to the federal government taking substantive action.

GcMAF: A “miracle cure” for everything from cancer to autism

So what is GcMAF? It’s a protein that is normally found in the blood of healthy people. It is an immunomodulatory protein, in that its activity affects the function of the immune system. The glycoprotein (a protein with sugar molecules attached) GcMAF results fromsequential deglycosylation of the vitamin D-binding protein (the Gc protein), and the resulting protein is felt to be a macrophage activating factor (MAF). MAFs are a class of protein known as a lymphokine, and they regulate the expression of antigens on the surface of macrophages. One of their functions is to “activate” macrophages, which can under the proper circumstances attack cancer cells. Of note, the production of GcMAF can be blocked by an enzyme called Nagalase (alpha-N-acetylgalactosaminidase), produced by many cancers, which led to its first incarnation in quackery as a “cure” for many cancers by Bill Sardi (remember him?) and Timothy Hubbell, based on dubious science and a clinical trial that didn’t show what its proponents claimed it did and was later retracted.

Bradstreet was a true believer in GcMAF as a cure for autism. For instance, check out this video of him promoting GcMAF as a cure for autism at the Treating Autism Conference at Brunel University in 2012

He starts out as saying he’s been studying HIV and that’s what connected him up with GcMAF, claiming that he noted elevated Nagalase activity in autistic children, which presumably results in lowered GcMAF levels. This resulted in a paper based on 40 autistic children that he published in Autism Insights in which he claimed to have found elevated Nagalase levels in autistic children that were reduced by injecting GcMAF. While it is possible that GcMAF injections could decrease Nagalase levels if they were pathologically elevated it just doesn’t seem particularly plausible. What GcMAF injections could theoretically do is simply bypass the activity of Nagalase (which, remember, blocks the production of GcMAF) and lead to increased GcMAF levels. And ultimately Bradstreet also claimed improvement in autistic symptoms. Of course, this was a single-arm uncontrolled study, so it’s not particularly compelling evidence. It was also published in what was, before it was discontinued, in essence a vanity journal whose editorial board was packed with autism quacks, including Andrew Wakefield, Bryan Jepson, and Arthur Krigsman.

Another study with which Bradstreet was involved, claimed that GcMAF could normalize abnormal gene expression in the endocannabinoid system of autistic children, which, of course, links his work with claims made by some in the “autism biomed” movement that medical marijuana treats autism. Of course, this was an unrandomized, unblinded study (other than one person carrying out a lab test, specifically Ki67-ir profiles).

Based on highly dubious science and clinical data, Bradstreet was an enthusiastic backer of GcMAF, working with David Noakes, the head of Immuno Biotech:

During the same U.K. trip, Bradstreet and Noakes made what was essentially a promotional video for Immuno Biotech and its brand of GcMAF, called First Immune.

“I’m here with Dr. Jeffrey Bradstreet from the U.S.A., the autism expert in the First Immune GcMAF laboratories,” Noakes said on camera. “Dr. Bradstreet has been using our GcMAF for 18 months and we’d like to thank you for, I think you’ve treated 900 children now?”

“Not just children,” Bradstreet boasted. “So the spectrum of my patients with autism ranges from somewhere around 18 months to goodness, somewhere around close to 40. So we’ve treated many adults with autism as well as chronic fatigue patients, cancer patients. So we’ve found application for a fairly broad number of disorders for the product.”


“Dr. Jeffrey Bradstreet has now treated over 2,000 autistic children with GcMAF and the results are well established,” according to one of Noakes’s Web sites. “85% improve, if only a little, and of them 15% have their autism eradicated. In all 3,000 children have been treated with GcMAF with similar results.”

Internet chatrooms reveal how desperate parents were drawn to these promises like moths to a flame.

The discussion forum on Autism Web shows hundreds of parents of autistic children seeking out alternative methods of treating, or even “curing,” their kids.

“We are doing GcMAF injections through Bradstreet,” began one thread in August of 2011. “It has been 5 weeks. Each shot is $90 so I’m hoping we will see something big soon. I would love to hear from anyone else that has been doing the treatment for longer than us.”

Dozens responded. The replies varied from wary to ecstatic.

Of course, lots of quack treatments for autism and other conditions have enthusiastic testimonials to back them up. What are less commonly seen are the negative testimonials, and Bradstreet has those:

“We have completed 20 shots of GcMAF so far. I am still waiting for the wow that everyone talks about,” one person wrote. Even worse, they described side effects including “crying and pains in his chest and stomach at least for first 3 days after the shot.”

“We are doing GcMAF injections. I have not seen any gains at all,” another person wrote. “I have seen the worse behaviors and tantrums. So after spending $1,300 for no gains and living in hell I am done with this.”

Others described nasty viral or bacterial infections which flared up after starting their kids on GcMAF.

“It came to a point where we couldn’t tolerate it any more,” an angry parent wrote.

These negative testimonials ultimately got the British health authorities’ attention.

The end of a quack empire

The problems with Bradstreet’s quackery led an Irish woman named Fiona O’Leary to begin investigating First Immune and complaining to UK health authorities. Her efforts led the authorities to act. The First Immune GcMAF production facility in the UK was raided by British health authorities earlier this year. They found that the facility did not meet Good Manufacturing Practice (GMP) standards and expressed concerns over the sterility of the medicine being produced and the equipment being used, leading to further concerns that the product could well be contaminated. More than 10,000 vials of GcMAF were seized and production was halted.

After O’Leary had complained to the FDA as well, four months later on June 18, the day before Bradstreet killed himself, the feds showed up at Bradstreet’s Buford, GA clinic, search warrant in hand. Had he been convicted Bradstreet could have faced up to 20 years in prison. Of course, we all know from a previous autism quackery conviction that Bradstreet would probably never have been jailed that long, given that sentences in these discussions are usually the maximum possible and seldom actually given under federal sentencing guidelines, but to see him in jail would have been sweet indeed, even if it were only for a couple of years. Antivaccinationists know that, which is why O’Leary has become a target of their wrath, with accusations of “murder” and not having a soul.

In any case, Bradstreet left, apparently fleeing to North Carolina, and drove three hours northeast to Lake Lure, NC, where he checked into a hotel. There he learned that a First Immune clinic run by Noakes had been shut down in an investigation of five deathsassociated with GcMAF treatments. In fairness, it’s not clear whether the deaths were due to GcMAF or just terminal patients dying, but Swiss officials were on the trail as well. Hours after learning of this, Bradford disappeared. He wasn’t seen alive again. Although the investigation is not complete, authorities are satisfied that Bradstreet had committed suicide.

Yet the conspiracy theories continue:

“I know it was murder,” the Immuno Biotech CEO said. “Dr. Bradstreet stated what we all know: that the MMR vaccine causes autism,” repeating a claim often wielded by anti-vaccine activists that’s been totally debunked. “And he was an expert witness in many court cases in the U.S.A. providing testimony to that effect. MMR is a multibillion dollar vaccine and this [GcMFA] hurts the profits of the MMR drug companies and that is why he was killed.”

In a half-hour phone interview, Noakes told The Post that he was convinced a vaccine company killed Bradstreet to protect its profits from the wonder “cure” that is GcMFA.

“He was raided by the FDA the day before his murder so the murder is now dressed up to look like suicide,” Noakes claimed.

“Why would a doctor use a gun?” he continued. “A doctor wouldn’t use a gun at all. He’d use barbiturates or a cocktail of drugs which are easily available to him and take no effort.”

While it’s true that doctors who kill themselves are indeed more than twice as likely to use self-poisoning with drugs or other substances than the general population, they’re actuallyjust as likely to use firearms, even in a population that doesn’t have many guns. In the gun-rich US, firearms are the most common method of physician suicide, being the method used for nearly half of physician suicides, only slightly less common than in the general population. So all the incredulous dismissals of the conclusion that Bradstreet killed himself, based on the belief that Bradstreet couldn’t have possibly killed himself with a gun because he’s a doctor and doctors don’t kill themselves that way, are complete nonsense based on misinformation about physician suicide. To cast doubt on suicide as a cause of Bradstreet’s death will require a lot more than a mistaken belief that doctors don’t kill themselves with firearms, because they do.

In reality, it’s clear that Jeff Bradstreet’s many years of applying his quackery to autistic children had finally—finally—caught up with him. I’m actually sorry that he killed himself, both for the pain it caused his family, but also because it means that Bradstreet ultimately escaped justice. It means he will never face a judge and jury for the many years he victimized autistic children with a wide variety of quackery. That saddens me, but I can still hope that Bradstreet’s co-conspirators face the justice he eluded.

GcMAF (Gc Protein derived Macrophage Activating Factor) occurs naturally in our bodies and activates macrophages to destroy cancerous cells and foreign invaders such as bacteria and viruses. Serious illnesses like cancer, HIV and viral hepatitis destroy GcMAF and so neutralizes our immune system to defend itself. This allows the disease to progress uncontrolled.

We use a small sample of serum from healthy human people to produce large amounts of new second generation GcMAF in our specialized sterile laboratory called aCell Processing Center (CPC). This highly active Second Generation Gc-MAF is injected intramuscularly (IM) or subcutaneously (SC) into the patient usually twice weekly, and in some cases 3 times weekly. Over a matter of weeks and months the immune system becomes strengthened through the activation of macrophages, and begins to eradicate cancer cells, viruses and bacteria. In addition to GcMAF injections, another form of GcMAF manufactured from high quality colostrum can be administered orally in the gut and sublingually in the mouth to activate macrophages in the lymphoid tissue.

General goals of GcMAF therapy are to:

  • Improve well-being and quality of life (QOL)
  • Return the patient to good health so that they are able to participate in regular lifestyle activities
  • Achieve long term survival
  • Enhance the effect of other therapies
  • Repair the immune system
  • Increase the number of monocytes (macrophages) and activate them to destroy cancer cells, viruses, bacteria and other pathogens in the body
  • Increase the rate of maturation of dendritic cells (DCs)

GcMAF therapy overview

  • One course of High Dose GcMAF is usually 48 doses for 6 months (2 times weekly administration).
  • For advanced disease, High Dose GcMAF may be administered 3 times weekly.
  • Additional courses may be required depending on stage of disease and other factors specific to each patient.
  • Treatment should be continued at the high dose as long as necessary while disease is present to destroy cancer cells, viruses, bacteria and other pathogens in the body.
  • For serious diseases we recommend a combination of GcMAF injection and dailyColostrum MAF by oral and sublingual administration for the most effective treatment.
  • Longer term maintenance doses of High Dose GcMAF may be important to reduce recurrence after all evidence of disease eradication.
  • Oral Colostrum MAF may be a convenient long term option to maintain health.

Other important points

  • Activating macrophages with High Dose GcMAF is an important part of any treatment program which can be used alone or in combination with most other therapies.
  • GcMAF works especially well in synergy with targeted therapies which don’t harm the immune system. Examples of targeted therapies include hormone therapies, monoclonal antibody drugs, small-molecule drugs, signal transduction inhibitors (HER2 inhibitors, BRAF inhibitors, EGFR inhibitors), angiogenesis inhibitors, immunotherapy drugs (such as drugs that target CTLA-4 protein).
  • Second Generation GcMAF has the advantage of having no side effects so treatment should be continued as long as necessary while disease is present. This is a significant advantage over many conventional therapies which have cumulative toxicity that limits their use.
  • GcMAF never stops working and will continue to activate macrophages while treatment is continued, either by GcMAF injections and/or oral administration of Colostrum GcMAF.
Our principle of treatment is, first do no harm.

Second generation GcMAF

Second generation Gc-MAF is produced using a new Patented process which was developed here in Japan by Saisei Mirai in collaboration with researchers from theUniversity of Tokushima who have been studying GcMAF for over 20 years. Our GcMAF is made in our sterile cell processing facility using this new and improved 2nd generation method which is 10-15 times more concentrated and is more active and stable than other GcMAF that is currently available. Importantly, this much higher concentration GcMAF has been clinically demonstrated to be largely free of any side effects in the great majority of patients and is much more stable because it is resistant to oxidation. Only low grade fever or eczema have been observed in about 1 out of 100 patients using GcMAF, but these were short-term effects.

First Generation GcMAF vs Saisei Mirai Second Generation GcMAF concentration

Concentration of 1st generation and Second Generation GcMAF
  • 0.5 ml of High Dose GcMAF is approximately 1500 ng GcMAF
  • Gc-MAF is a natural immunotherapy product. Variation in GcMAF concentration is due to normal variation between serum samples. In the same way that Lymphocytes or Natural Killer cells vary in number between people and at any given time, so will the amount of GcMAF that can be produced from serum.
  • Our GcMAF is produced under aseptic conditions in a specialized facility and sterile filtration is used in the production of all product.
  • Our new 2nd generation Gc-MAF has been safely used in hundreds of patients in our clinics in Japan, since April 2011. Treatment in our clinics has been by Intramuscular (IM), Subcutaneous (SC), and Intratumoral (IT) injection

How is our second generation GcMAF made?

Second generation GcMAF is manufactured in our own sterile Saisei Mirai Cell Processing Center (CPC) from serum of healthy people which is carefully screened and the final product sterile filtered to ensure safety. See Tests of our GcMAF below for more details.

Diagram showing steps of our GcMAF preparation process
Steps of High Dose GcMAF production

How is our second generation GcMAF tested for activity?

Our second generation GcMAF is tested for macrophage phagocytic activity using mouse macrophages and sheep red blood cells at the University of Tokushima. The red blood cells are opsonized which marks them for ingestion and destruction by activated macrophages, seen as purple areas in the clear cells. From this we calculate the Phagocytosis (ingestion) Index (PI).

Macrophage phagocytic activity of Second Generation GcMAF
Macrophage phagocytic activity of second generation GcMAF. The purple color are macrophages activated by GcMAF phagocytizing (ingesting) opsonized red blood cells which are clear in color. (Photo courtesy, University of Tokushima)

What are macrophages?

Macrophages (Greek: big eaters) are cells produced by the differentiation of monocytes, a type of white blood cell, in tissues. Macrophages function in both non-specific defense (innate immunity) as well as help initiate specific defense mechanisms (adaptive immunity) of vertebrate animals. Their role is to phagocytose (engulf and then digest) cellular debris and pathogens, either as stationary or as mobile cells. They also stimulate lymphocytes and other immune cells to respond to pathogens. They are specialized phagocytic cells that attack foreign substances, infectious microbes and cancer cells through destruction and ingestion.

Steps of a macrophage ingesting a pathogen
Steps of a macrophage ingesting a pathogen
a. Ingestion through phagocytosis, a phagosome is formed
b. The fusion of lysosomes with the phagosome creates a phagolysosome; the pathogen is broken down by enzymes
c. Waste material is expelled or assimilated (the latter not pictured)Parts: 1. Pathogens, 2. Phagosome, 3. Lysosomes, 4. Waste material, 5. Cytoplasm,6. Cell membrane

Vitamin D binding protein

Vitamin D binding protein is also known as Gc Protein. It is produced in our body, mainly in the liver, especially when we are exposed to the sun. This binding protein binds to 25 (OH) vitamin D in our body for transport and storage. There are different forms of Vitamin D BP, the most dominant being non-glycosylated 656 Da proteins. Vitamin DBP is the most important scavenger of extracellular G-actin, important in liver disease. Vitamin DBP activates macrophages through GaINAc- modified Gc Protein. Vitamin DBP has virtually no impact on the distribution, uptake, activation profile, or biological potency of the hormone vitamin D in our body, so too much is unlikely to be a problem. Vitamin D binding protein is the basic macrophage activating factor in our body.

Factors that influence Vitamin DBP levels

Liver disease decreases levels of Vitamin DBP (Gc Protein). Chronic liver disease will decrease levels less than acute liver failure. Trauma and surgery will decrease Vitamin DBP. Septic infections will consume Vitamin DBP faster than production can be increased.

Normal Vitamin DBP (Gc Protein) levels in serum are 350-500 mg/l. Levels of Gc Protein less than 80 mg/l yield positive and negative mortality predictive values of 85% and 43% respectively. Survivors had levels greater than 102 mg/l.

Macrophage activation factor (MAF)

What is macrophage activation factor?

Macrophage activation factor (MAF) are glycoproteins that increase macrophage activity and transform them into natural killer (NK) cells. Vitamin DBP (Gc Protein) is the primary MAF. The glycosylated Gc Protein is the best MAF.

NaGaLase (Alpha-N-acetylgalactosaminidase)

NaGaLase is an enzyme produced in trace amounts in normal healthy liver cells.

What harm can NaGaLase do?

Alpha-N-acetylgalactosaminidase (alpha-NaGaLase) is produced in large amounts by cancer cells. alpha-NaGaLase deglycosylates the trisaccharide of Gc Protein at step prior to the final isoform of MAF. alpha-NaGaLase from tumors induces an immunosuppressive state that allows the cancer to spread and eventually results in death by infection.

What good can NaGaLase do?

Endo-alpha-N-acetylgalactosaminidase is produced in small amounts by probiotic bifodobacterium. NaGaLase produced in the intestine by our probiotics serves a role in breaking down mucin glycoproteins in our food.

Where else is NaGaLase found?

NaGaLase is also produced by bacteria, virus infected cells and fungi.

Normal serum levels of NaGaLase

Normal levels of NaGaLase range between 0.38 to 0.63 nmole/min/mg protein. People with cancer have NaGaLase above 2.32 nmole/min/mg protein.

Radiation therapy decreases the number of cancerous cells capable of secreting alpha-NaGaLase. Radiation also increases Gc Protein activation to principle MAF. Radiotherapy and photodynamic therapy decreases NaGaLase activity.

Target diseases for GcMAF therapy

  • Gc-MAF macrophage activation therapy is useful in the treatment of many diseases, such as cancer, HIV AIDS, Hepatitis B virus (HBV), Hepatitis C virus (HCV), Herpes Simplex virus (HSV), Tuberculosis, Pneumonia infection, Epstein-Barr virus (EBV), cystitis/urinary tract infection (UTI), Endometriosis, Selective IgA deficiency disorder and influenza virus.
  • In healthy individuals the immune system may be able to overcome many kinds of diseases, however people with a compromised immune system will benefit from GcMAF therapy.
  • In the great majority of people there are no side-effects with our2nd generation Gc-MAF therapy, or side-effects are very minor and extremely rare. Low grade fever and eczema has been observed in about 1 out of 100 patients using GcMAF, but these were short-term effects.
  • Treatment in our clinics has been by Intramuscular (IM), Subcutaneous (SC), and Intratumoral (IT) injection.

In combination with other treatments

GcMAF can be safely used with a wide variety of other standard treatments and drugs to improve their effect. We refer to this as integrative medicine.

  • In combination with anti-cancer drugs and radiation therapy (radiotherapy) is possible. For maximum effect and benefit from GcMAF, administer a few days apart from chemotherapy. Radiation therapy does not have significant effects on Gc-MAF, so both can be used together at any time. In our clinical experience we have observed significant cancer killing effects from GcMAF combined with palliative radiotherapy in patients who have had significant prior treatment with chemotherapy. See our Case Reports for more details on this multimodality integrative treatment.
  • Studies show that GcMAF has anti-angiogenic activity in addition to tumor killing activity through the activation of macrophages.
  • GcMAF can be combined with Sonodynamic Therapy (SDT), Photodynamic Therapy (PDT) or both (Sonophotodynamic Therapy, SPDT), Maitake Extract, Coley Vaccine (Coley Fluid), high dose IV Vitamin C, low dose Naltrexone (LDN), Alpha-Lipoic Acid, hyperthermia therapy, immunotherapies and cancer vaccines (such as autologous cancer vaccine).
  • GcMAF should be used in combination with at least 5,000 IU vitamin D3 daily. Blood levels of vitamin D are often low in many kinds of diseases, such as cancer, HIV AIDS, etc. Normal vitamin D levels are necessary in order for GcMAF to work fully. Ask to have your blood 25 hydroxy-vitamin D as well as calciumlevels tested. If blood calcium levels become elevated, the dose of vitamin D3 may need to be reduced to achieve optimal balance.

Things to avoid

Gc-MAF can be safely used with a wide variety of drugs and other treatments however we recommend:

  • Minimal use of steroids is desirable because of their immune suppressing effect, however steroids may be safely used with GcMAF if necessary and prescribed by your doctor.
  • Radiation therapy is preferred over chemotherapy, if possible.


  • Treatment is by Intramuscular (IM) or Subcutaneous (SC) injection of GcMAF macrophage activating factor, 1-2 times per week (or as prescribed by the treating medical doctor). See Dosing recommendations below.
  • Treatment in our clinics has also been by Intratumoral (IT) injection, although IM and SC injection is by far the most common means of administration.
  • Good aseptic technique with ethanol is required when using the vials.

Dosing recommendations for Second Generation GcMAF

  • Dosage and frequency of Gc-MAF administration is at the discretion of the treating doctor and/or the patient.
  • No upper limit has been established for second generation GcMAF.
Cancer, HIV AIDS, Hepatitis, Tuberculosis:

For cancer patients, HIV AIDS, Hepatitis, Tuberculosis we suggest 1500 ng High Dose GcMAF once or twice per week.

  • For maximum effect we recommend 0.5 ml twice weekly.
  • One course of High Dose GcMAF is usually 48 doses for 6 months. Additional courses may be required depending on stage of disease and severity of symptoms.

Macrophage activation is always necessary for the effective functioning of the immune system. Gc-MAF therapy should continue while there is disease present and for a period after to reduce the chance of recurrence.

Chronic Fatigue Syndrome (CFS)/Myalgic Encephalomyelitis (ME):

In Chronic Fatigue Syndrome (CFS) and Myalgic Encephalomyelitis (ME), a lower dosage of 100 ng Low Dose GcMAF once per week is commonly recommended. With Second Generation GcMAF we recommend using High Dose GcMAF for more effective treatment.

    • Recommended dose – 0.25ml High Dose GcMAF, twice weekly by intramuscular or subcutaneous injection. *
  • Some improvements in symptoms should be observed within 2 months.
  • Minimum treatment course of 6 months should be expected, but each patient is different and additional courses may be required based on positive progress.
  • Patients may need longer term maintenance doses of GcMAF therapy to stay well and symptom free until their immune system is fully recovered enough to cope with challenges.
  • If patients are are already using 100 ng Low Dose GcMAF and the effects from the treatment are not pronounced, we recommend switching to Second Generation High Dose GcMAF.
  • In our clinics in Japan, all of our patients, regardless of the disease, use second generation High Dose GcMAF.

* These dosage recommendations apply only to Saisei Mirai Second Generation GcMAF.

Autism Spectrum Disorders (ASD):
    • Recommended dose – 0.25ml High Dose GcMAF, twice weekly by intramuscular or subcutaneous injection. *
  • Some improvements in symptoms should be observed within 2 months.
  • Minimum treatment course of 6 months should be expected, but each individual patient is different and additional courses may be required based on positive progress.
  • Patients may need longer term maintenance doses of GcMAF therapy to stay well and symptom free until their immune system is fully developed enough to cope with challenges.
  • See our Autism Spectrum Disorders (ASD) page for more details on Autism.

* These dosage recommendations apply only to Saisei Mirai Second Generation GcMAF.

GcMAF Therapy

If you wish to get GcMAF therapy, please contact us by email with details of your disease, current treatment and the quantities of GcMAF you require. Below are details about pricing and payment.

High Dose GcMAF 2.5 ml multi-dose vials (1500 ng/0.5 ml):

2 vials x 2.5 ml GcMAF (1500 ng/0.5 ml) 8 doses — please contact us for pricing

4 vials x 2.5 ml GcMAF (1500 ng/0.5 ml) 16 doses — please contact us for pricing

6 vials x 2.5 ml GcMAF (1500 ng/0.5 ml) 24 doses — please contact us for pricing

  • Each multi-dose vial contains at least 4 doses GcMAF at 0.5 ml/dose. Vials are overfilled to 2.5 ml, so up to 5 doses GcMAF may be possible for each vial.
  • Prices include 8200 yen for shipping and handling by EMS International Express Mail Service worldwide. Shipping can be calculated for other couriers such as UPS.
  • Keep vials refrigerated at around 2-8 °C for multi-dose use. For long term storage > 1 year, vials maybe be kept frozen and defrosted once for multi-dose use. Due to much improved stability of our second generation GcMAF, freezing is usually not necessary.

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